Our partner, Ichimaru Pharcos, plays a particularly active role in basic research. Its areas of investigation essentially focus on cell nucleus metabolism. Based on the results obtained, cosmetic active substances that target the very heart of cells can thus be developed. The latest newcomer to this novel generation of active substances is Dermaveil, an extract of white willow bark, which ensures a uniform, moisturised and radiant skin.

An innovative mode of action

The transcription factor (nuclear receptor) PPAR (peroxisomal proliferator activated receptor) is considered to be one of the factors specifically acting on lipid and protein metabolism as well as on cell division. PPAR β/δ is the most important transcription factor in the epidermis. It is believed to be capable of promoting cell maturation to restore soft skin, eliminating any signs of dryness or roughness.

Dermaveil: the key active substance

After numerous plant screening procedures, an extract of white willow bark has been found to have a major effect on PPAR β/δ activation. Thanks to Dermaveil (INCI: Water + Butylene Glycol + Salix Alba (Willow) Bark Extract), we therefore offer a new, high-performance mode of action, restoring softness and comfort to the skin.
Activation of this nuclear receptor promotes the formation of proteins that are essential for the division and maturation of epidermal keratinocytes. Amongst these proteins, involucrin is especially renowned for combating rough skin and restoring a smooth appearance. What’s more, by reverting the stratum corneum to normal, Dermaveil restores the barrier function of the skin and boosts the moisture content.

Finally, in-vivo tests carried out by Ichimaru Pharcos confirm the efficacy of the short-term application of low doses of Dermaveil: a return to normal cornification of the skin was observed in all of the test subjects within two weeks.